PptT inhibitor 8918 ( Compound 8918 )

产品货号. M15469 CAS No. 65009-19-0

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产品名称

PptT inhibitor 8918
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM).
产品描述

PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM), shows an MIC90 of 3.1 uM against Mtb H37Rv; also exhibits MIC90s ranged from 0.56-3.0 uM (median 1.5 uM) against 29 clinical isolates of Mtb; inhibits growth of WT Mtb, but not of the pptT mutant W170S or WT Mtb expressing the pptT W170S mutant; kills Mycobacterium tuberculosis (Mtb) by binding and partially inhibiting PptT.
同义词

Compound 8918
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

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适应症

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1. Ballinger E, et al. Science. 2019 Feb 1;363(6426). pii: eaau8959. doi: 10.1126/science.aau8959.

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